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irk Deleu graduated
with 'magna cum laude' from the Medical School of the University of Brussels
(Vrije Universiteit Brussel) in 1983. He pursued his postgraduate residency
training in Neurology at the same institution and became board certified
Neurologist in 1988. Subsequently, he became permanently affiliated to the
Department of Neurology at the University Hospital of Brussels (Akademisch
Ziekenhuis Vrije Universiteit Brussel)(www.az.vub.ac.be).
Very early in his medical training he became interested in neuropharmacology
and neurochemistry which prompted him as a last year medical student to
start at the same time his medical research, which was focused on the regional distribution of
acidic dopamine metabolites in human brain. During his residency in Neurology,
he became more involved in movement disorders and particularly the neuropharmacologic
aspects of Parkinson's disease. He obtained several academic titles (M.Sc.,
Ph.D.) at his mother institution and received his Professorial degree (Aggregaatsthesis
van het Hoger Onderwijs) in 1994. His thesis focused on the study of the
peripheral pharmacokinetics and metabolism of levodopa using microdialysis.
He has over 100 publications covering all fields of neuroscience and
is an active member of several international editorial and review
boards. His contribution to neurology has resulted in his election
as Fellow of the American Academy of Neurology and Fellow of the
Royal College of Physicians (Edinburgh). An overview of the author's
curriculum vitae can be found at CV.
From 1993,
Dirk Deleu was affiliated to Sultan Qaboos University and its teaching Hospital
(Sultan Qaboos University Hospital) in the Sultanate of Oman. In
August 2003, he joined the Department of Neurology (Medicine) at Hamad Medical
Corporation (www.hmc.org.qa) in Doha, State of Qatar.
He is currently Senior Consultant and Head of Neurology and
Neurophysiology, and
Professor Clinical Neurology & Neurosciences at Weill Cornell
Medical College - Qatar and has been appointed as Regional Adviser
to the Royal College of Physicians of Edinburgh.
The author
wishes to acknowledge Kathy & Ellen Deleu for their technical and
scientific contributions in the development of the website.
Selection of publications:
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Deleu D, Solheid C, Michotte
A, et al. Dissociated ipsilateral horizontal gaze palsy in one-and-a-half
syndrome: A clinicopathologic study. Neurology 1988;38:1278-1280.
-
Deleu D, Ebinger G, Michotte
Y. A clinical and pharmacokinetic comparison of oral and duodenal delivery
of levodopa/carbidopa in patients with Parkinson's disease with fluctuating
responses to levodopa. European Journal of Clinical Pharmacology
1991;41:453-458.
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Sarre S, Herregodts P,
Deleu D, et al. Biotransformation
of L-DOPA in striatum and substantia nigra in rats with unilateral nigrostriatal
lesion: a microdialysis study. Naunyn-Schmiedeberg's Archives of Pharmacology
1992;346:277-285.
-
Deleu D, Sarre S, Ebinger
G, et al. The effect of carbidopa and entacapone pretreatment on the
L-DOPA pharmacokinetics and metabolism in blood plasma and skeletal muscle
in beagle dog: An in vivo microdialysis study.
Journal of Pharmacology and Experimental Therapeutics
1995;273:1323-1331.
-
Deleu D, Hanssens Y. Loss of aura in
lamotrigine-treated epilepsy. Lancet 1997;350:1751-1752.
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Deleu D, Bamanikar S, Muirhead D,
et al. Familial progressive sensorimotor neuropathy with agenesis of the corpus
callosum (Andermann syndrome): a clinical, neuroradiological and histopathological
study. European Neurology 1997;37:104-109.
-
Deleu D, Northway M, Hanssens Y. Clinical
pharmacokinetic and pharmacodynamic properties of drugs used in the treatment
of Parkinson's disease. Clinical Pharmacokinetics 2002;41:261-309.
-
Deleu D, Khan MA, Al Shehab T. Prevalence
and clinical characteristics of headache in a rural community in Oman.
Headache 2002;42:963-973.
-
Deleu
D. Levetiracetam in the treatment of idiopathic hemifacial
spasm. Neurology 2004;62:2134-2135.
-
Deleu
D, Hanssens Y, Northway M.
Subcutaneous apomorphine : an evidence-based
review of its use in Parkinson's disease.
Drugs Aging 2004;21:687-709.
-
Deleu
D, Aarons L, Ahmed I.
Estimation of population pharmacokinetic
parameters of free-phenytoin in adult epileptic patients.
Archives of Medical Research 2005;36:49-53.
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Deleu
D, Hamad AA, Kamram S, et al.
Ethnic variations in risk factor profile, pattern and
recurrence of non-cardioembolic ischemic stroke.
Archives of Medical Research
2006;37:655-662.
-
Deleu
D, Jacob P, Chand P, et al. Effects of caffeine
on levodopa pharmacokinetics and pharmacodynamics in
Parkinson's disease.
Neurology
2006;67:897-899.
-
Deleu
D, Kamran S, Hamad AA, et al. Segmental
ventricular wall motion abnormalities are associated with lacunar ischemic stroke. Clinical Neurology and
Neurosurgery 2006;108:744-749.
-
Deleu
D. Levodopa, motor complications and disease progression.
Journal of Neurological Sciences 2008;273:155-69.
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Akhtar N, Kamran S, Deleu
D, et al. Pattern of ischemic posterior circulation stroke
in the state of Qatar.
European
Journal of Neurology
(in press).
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